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Corpus callosum involvement and postoperative outcomes of patients with gliomas.
Chen, Ko-Ting; Wu, Tai-Wei Erich; Chuang, Chi-Cheng; Hsu, Yung-Hsin; Hsu, Peng-Wei; Huang, Yin-Cheng; Lin, Tzu-Kang; Chang, Chen-Nen; Lee, Shih-Tseng; Wu, Chieh-Tsai; Tseng, Chen-Kan; Wang, Chun-Chieh; Pai, Ping-Ching; Wei, Kuo-Chen; Chen, Pin-Yuan.
Afiliação
  • Chen KT; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Wu TW; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Chuang CC; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Hsu YH; School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
  • Hsu PW; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Huang YC; School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
  • Lin TK; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Chang CN; School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
  • Lee ST; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Wu CT; School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
  • Tseng CK; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Wang CC; School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
  • Pai PC; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
  • Wei KC; School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
  • Chen PY; Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
J Neurooncol ; 124(2): 207-14, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26033546
Corpus callosum involvement is associated with poorer survival in high grade glioma (HGG), but the prognostic value in low grade glioma (LGG) is unclear. To determine the prognostic impact of corpus callosum involvement on progression free survival (PFS) and overall survival (OS) in HGG and LGG, the records of 233 glioma patients treated from 2008 to 2011 were retrospectively reviewed. Preoperative magnetic resonance (MR) images were used to identify corpus callosum involvement. Age, sex, preoperative Karnofsky performance scale, postoperative Eastern Cooperative Oncology Group (ECOG) score and extent of resection (EOR) were evaluated with respect to PFS and OS. The incidence of corpus callosum involvement was similar among HGG (14 %) and LGG (14.5 %). Univariate analysis revealed that PFS and OS were significantly shorter in both WHO grade II and grade IV glioma with corpus callosum involvement (both, p < 0.05). Multivariate analysis showed that grade II glioma with corpus callosum involvement have shorter PFS (p = 0.03), while EOR, instead of corpus callosum involvement (p = 0.16), was an independent factor associated with PFS in grade IV glioma (p < 0.05). Corpus callosum involvement was no longer significantly associated with OS after adjusting age, gender, EOR, preoperative and postoperative performance status (p = 0.16, 0.17 and 0.56 in grade II, III and IV gliomas, respectively). Corpus callosum involvement happened in both LGG and HGG, and is associated with lower EOR and higher postoperative ECOG score both in LGG and HGG. Corpus callosum involvement tends to be an independent prognostic factor for PFS in LGG, but not for OS in LGG or in HGG.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Corpo Caloso / Glioma Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Corpo Caloso / Glioma Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article