Hepassocin is required for hepatic outgrowth during zebrafish hepatogenesis.
Biochem Biophys Res Commun
; 463(3): 466-71, 2015 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-26047702
ABSTRACT
BACKGROUND & AIMS:
Hepassocin (HPS) is a hepatotrophic growth factor that specifically stimulates hepatocyte proliferation and promotes liver regeneration after liver damage. In this paper, zebrafish were used to investigate the role of HPS in liver development. METHODS ANDRESULTS:
During zebrafish development, HPS expression is enriched in liver throughout hepatogenesis. Knockdown of HPS using its specific morpholino leads to a smaller liver phenotype. Further results showed that the HPS knockdown has no effect on the expression of the early endoderm marker gata6 and early hepatic marker hhex. In addition, results showed that the smaller-liver phenotype in HPS morphants was caused by suppression of cell proliferation, not induction of cell apoptosis.CONCLUSIONS:
Current findings indicated that HPS is essential to the later stages of development in vertebrate liver organogenesis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
/
Proteínas de Peixe-Zebra
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article