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Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.
Fauber, Benjamin P; Gobbi, Alberto; Robarge, Kirk; Zhou, Aihe; Barnard, Adrian; Cao, Jianhua; Deng, Yuzhong; Eidenschenk, Céline; Everett, Christine; Ganguli, Arunima; Hawkins, Julie; Johnson, Adam R; La, Hank; Norman, Maxine; Salmon, Gary; Summerhill, Susan; Ouyang, Wenjun; Tang, Wei; Wong, Harvey.
Afiliação
  • Fauber BP; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: Fauber.Benjamin@gene.com.
  • Gobbi A; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Robarge K; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhou A; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Barnard A; Argenta, Units 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.
  • Cao J; ChemPartner, No. 5 Building, 998 Halei Road, Zhangjiang Hi-Tech Park Pudong New Area, Shanghai 201203, China.
  • Deng Y; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Eidenschenk C; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Everett C; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ganguli A; Argenta, Units 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.
  • Hawkins J; Argenta, Units 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.
  • Johnson AR; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • La H; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Norman M; Argenta, Units 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.
  • Salmon G; Argenta, Units 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.
  • Summerhill S; Argenta, Units 7-9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.
  • Ouyang W; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Tang W; ChemPartner, No. 5 Building, 998 Halei Road, Zhangjiang Hi-Tech Park Pudong New Area, Shanghai 201203, China.
  • Wong H; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett ; 25(15): 2907-12, 2015 Aug 01.
Article em En | MEDLINE | ID: mdl-26048793
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirimidinas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Imidazóis Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirimidinas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Imidazóis Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article