Practicalities of using a modified version of the Cochrane Collaboration risk of bias tool for randomised and non-randomised study designs applied in a health technology assessment setting.
Res Synth Methods
; 5(3): 200-11, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-26052846
ABSTRACT
UNLABELLED We describe our experience of using a modified version of the Cochrane risk of bias (RoB) tool for randomised and non-randomised comparative studies. OBJECTIVES:
To assess time to complete RoB assessment. To assess inter-rater agreement. To explore the association between RoB and treatment effect sizeMETHODS:
Cochrane risk of bias assessment was performed on a sample of full text primary reports included in a systematic review comparing operative techniques for radical prostatectomy. Inter-rater agreement was assessed using the kappa statistic.RESULTS:
Twenty-four studies were judged as high overall RoB, 13 were judged as low RoB and 11 were unclear. The weighted Kappa value was 0.35 indicating fair agreement. The median (range) time taken to rate each study was 30 min (10-49). The effect estimate for all studies was 0.61 (95% credible interval (CrI) 0.46-0.83) and 0.73 (95% CrI 0.29-1.75) for low risk studies.CONCLUSIONS:
Although the process was time consuming, using a modified version of the RoB tool proved useful for demonstrating conservative effect estimates. That we only achieved a fair agreement between reviewers demonstrates the urgent need for further validation to improve inter-rater agreement. We suggest additional RoB levels could improve inter-rater reliability.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Avaliação da Tecnologia Biomédica
/
Software
/
Viés
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Avaliação de Resultados em Cuidados de Saúde
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Health_technology_assessment
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article