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Assessment of adhesion, invasion and cytotoxicity potential of oral Staphylococcus aureus strains.
Merghni, Abderrahmen; Ben Nejma, Mouna; Helali, Imen; Hentati, Hajer; Bongiovanni, Antonino; Lafont, Frank; Aouni, Mahjoub; Mastouri, Maha.
Afiliação
  • Merghni A; Laboratoire des Maladies Transmissible et Substances Biologiquement Actives, LR99ES27, Faculté de Pharmacie de Monastir, Université de Monastir, Tunisia. Electronic address: Abderrahmen_merghni@yahoo.fr.
  • Ben Nejma M; Laboratoire des Maladies Transmissible et Substances Biologiquement Actives, LR99ES27, Faculté de Pharmacie de Monastir, Université de Monastir, Tunisia.
  • Helali I; Laboratoire des Maladies Transmissible et Substances Biologiquement Actives, LR99ES27, Faculté de Pharmacie de Monastir, Université de Monastir, Tunisia.
  • Hentati H; Service de Médecine et chirurgie buccales, Clinique universitaire de médecine dentaire, Monastir, Tunisia.
  • Bongiovanni A; BioImaging Center Lille-Nord de France, Lille, France.
  • Lafont F; BioImaging Center Lille-Nord de France, Lille, France; Cellular Microbiology and Physics of Infection Group, Center for Infection and Immunity of Lille-CNRS UMR8204, INSERM U1019, Institut Pasteur de Lille, Lille University, France.
  • Aouni M; Laboratoire des Maladies Transmissible et Substances Biologiquement Actives, LR99ES27, Faculté de Pharmacie de Monastir, Université de Monastir, Tunisia.
  • Mastouri M; Laboratoire des Maladies Transmissible et Substances Biologiquement Actives, LR99ES27, Faculté de Pharmacie de Monastir, Université de Monastir, Tunisia; Laboratoire de Microbiologie, CHU Fatouma Bourguiba de Monastir, Tunisia.
Microb Pathog ; 86: 1-9, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26055540
ABSTRACT
The oral cavity is regarded as a relevant site for Staphylococcus aureus colonization. However, characterization of virulence mechanisms of oral S. aureus remains to be uncovered. In this study, twenty one S. aureus strains isolated from the oral cavity of Tunisian patients were screened for adherence, invasion and cytotoxicity against HeLa cells. In addition, the presence of adhesins (icaA, icaD, can, fnbA and fnbB) and α-hemolysin (hla) genes in each strain was achieved by polymerase chain reaction (PCR). Our finding revealed that oral S. aureus strains were able to adhere and invade epithelial cells, with variable degrees (P < 0.05). Moreover they exhibited either low (23.8%) or moderate (76.2%) cytotoxic effects. In addition 76.2% of strains were icaA and icaD positive and 90.5% harbor both the fnbA and the fnbB gene. While the cna gene was detected in 12 strains (57.2%). Furthermore, the hla gene encoding the α-toxin was found in 52.4% of the isolates. All these virulence factors give to S. aureus the right qualities to become a redoubtable pathogen associated to oral infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Aderência Bacteriana / Endocitose Limite: Humans País/Região como assunto: Africa Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Aderência Bacteriana / Endocitose Limite: Humans País/Região como assunto: Africa Idioma: En Ano de publicação: 2015 Tipo de documento: Article