Strategic development of a multivariate calibration model for the uniformity testing of tablets by transmission NIR analysis.
Pharmazie
; 70(5): 289-95, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-26062295
ABSTRACT
The use of transmission near infrared spectroscopy (TNIRS) is of particular interest in the pharmaceutical industry. This is because TNIRS does not require sample preparation and can analyze several tens of tablet samples in an hour. It has the capability to measure all relevant information from a tablet, while still on the production line. However, TNIRS has a narrow spectrum range and overtone vibrations often overlap. To perform content uniformity testing in tablets by TNIRS, various properties in the tableting process need to be analyzed by a multivariate prediction model, such as a Partial Least Square Regression modeling. One issue is that typical approaches require several hundred reference samples to act as the basis of the method rather than a strategically designed method. This means that many batches are needed to prepare the reference samples; this requires time and is not cost effective. Our group investigated the concentration dependence of the calibration model with a strategic design. Consequently, we developed a more effective approach to the TNIRS calibration model than the existing methodology.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comprimidos
/
Espectroscopia de Luz Próxima ao Infravermelho
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article