Animal Models--Decoding the Molecular Biology of Oral Cancer.
J Contemp Dent Pract
; 16(4): i-ii, 2015 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-26067740
ABSTRACT
Animal models have long been used to understand the initiation and progression of carcinogenesis, including that of oral mucosa.(1) One of the earliest models used was the chemical-induced oral cancer model, among which the Syrian Hamster check pouch was preferred for its ideal anatomical location and physiological features.(2) Salley et al(3) demonstrated that the cheek pouch mucosa underwent gradual changes from hyperplasia, carcinoma in situ to squamous cell carcinoma when exposed to polycyclic hydrocarbon 9, 10 dimethyl-1,2, benzanthracene (DMBA). Morris(4) standardized the dosage of carcinogen to 0.5% solution of DMBA in acetone and established that 5-week old animals were ideal to induce tumor with minimum time lag and maximum yield. Lin et al(5) demonstrated the synergistic effect of arecaidine with DMBA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article