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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.
Mukherjee, Rajarshi; Mareninova, Olga A; Odinokova, Irina V; Huang, Wei; Murphy, John; Chvanov, Michael; Javed, Muhammad A; Wen, Li; Booth, David M; Cane, Matthew C; Awais, Muhammad; Gavillet, Bruno; Pruss, Rebecca M; Schaller, Sophie; Molkentin, Jeffery D; Tepikin, Alexei V; Petersen, Ole H; Pandol, Stephen J; Gukovsky, Ilya; Criddle, David N; Gukovskaya, Anna S; Sutton, Robert.
Afiliação
  • Mukherjee R; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Mareninova OA; Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA.
  • Odinokova IV; Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA Institute of Theoretical and Experimental Biophysics, Russian Academy of Scienc
  • Huang W; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK Department of Integrated Traditional and Western Medicine, Sichuan Provincial Pancreatitis Centre, West China Hospital, Sic
  • Murphy J; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Chvanov M; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Javed MA; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Wen L; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Booth DM; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Cane MC; Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Awais M; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Gavillet B; Debiopharm Research and Manufacturing S.A., Lausanne, Switzerland.
  • Pruss RM; Trophos S.A., Marseille, France.
  • Schaller S; Trophos S.A., Marseille, France.
  • Molkentin JD; Howard Hughes Medical Institute, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Tepikin AV; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Petersen OH; Cardiff School of Biosciences, University of Cardiff, Cardiff, Wales, UK.
  • Pandol SJ; Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA.
  • Gukovsky I; Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA.
  • Criddle DN; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
  • Gukovskaya AS; Veterans Affairs Greater Los Angeles Healthcare System, University of California Los Angeles and Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Los Angeles, California, USA.
  • Sutton R; NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool, UK Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Gut ; 65(8): 1333-46, 2016 08.
Article em En | MEDLINE | ID: mdl-26071131
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pâncreas / Fosfoproteínas Fosfatases / Pancreatite Necrosante Aguda / Proteínas Mitocondriais / Proteínas de Transporte da Membrana Mitocondrial / Células Acinares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pâncreas / Fosfoproteínas Fosfatases / Pancreatite Necrosante Aguda / Proteínas Mitocondriais / Proteínas de Transporte da Membrana Mitocondrial / Células Acinares Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article