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Analysis of cardiovascular responses to the H2S donors Na2S and NaHS in the rat.
Yoo, Daniel; Jupiter, Ryan C; Pankey, Edward A; Reddy, Vishwaradh G; Edward, Justin A; Swan, Kevin W; Peak, Taylor C; Mostany, Ricardo; Kadowitz, Philip J.
Afiliação
  • Yoo D; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Jupiter RC; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Pankey EA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Reddy VG; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Edward JA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Swan KW; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Peak TC; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Mostany R; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
  • Kadowitz PJ; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana pkadowi@tulane.edu.
Am J Physiol Heart Circ Physiol ; 309(4): H605-14, 2015 Aug 15.
Article em En | MEDLINE | ID: mdl-26071540
Hydrogen sulfide (H2S) is an endogenous gaseous molecule formed from L-cysteine in vascular tissue. In the present study, cardiovascular responses to the H2S donors Na2S and NaHS were investigated in the anesthetized rat. The intravenous injections of Na2S and NaHS 0.03-0.5 mg/kg produced dose-related decreases in systemic arterial pressure and heart rate, and at higher doses decreases in cardiac output, pulmonary arterial pressure, and systemic vascular resistance. H2S infusion studies show that decreases in systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance are well-maintained, and responses to Na2S are reversible. Decreases in heart rate were not blocked by atropine, suggesting that the bradycardia was independent of parasympathetic activation and was mediated by an effect on the sinus node. The decreases in systemic arterial pressure were not attenuated by hexamethonium, glybenclamide, N(w)-nitro-L-arginine methyl ester hydrochloride, sodium meclofenamate, ODQ, miconazole, 5-hydroxydecanoate, or tetraethylammonium, suggesting that ATP-sensitive potassium channels, nitric oxide, arachidonic acid metabolites, cyclic GMP, p450 epoxygenase metabolites, or large conductance calcium-activated potassium channels are not involved in mediating hypotensive responses to the H2S donors in the rat and that responses are not centrally mediated. The present data indicate that decreases in systemic arterial pressure in response to the H2S donors can be mediated by decreases in vascular resistance and cardiac output and that the donors have an effect on the sinus node independent of the parasympathetic system. The present data indicate that the mechanism of the peripherally mediated hypotensive response to the H2S donors is uncertain in the intact rat.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfetos / Resistência Vascular / Pressão Sanguínea / Débito Cardíaco / Frequência Cardíaca / Sulfeto de Hidrogênio Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfetos / Resistência Vascular / Pressão Sanguínea / Débito Cardíaco / Frequência Cardíaca / Sulfeto de Hidrogênio Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article