Aryl H-Phosphonates 18. Synthesis, properties, and biological activity of 2',3'-dideoxynucleoside (N-heteroaryl)phosphoramidates of increased lipophilicity.

Kolodziej, Krystian; Romanowska, Joanna; Stawinski, Jacek; Boryski, Jerzy; Dabrowska, Aleksandra; Lipniacki, Andrzej; Piasek, Andrzej; Kraszewski, Adam; Sobkowski, Michal

Kolodziej, Krystian; Romanowska, Joanna; Stawinski, Jacek; Boryski, Jerzy; Dabrowska, Aleksandra; Lipniacki, Andrzej; Piasek, Andrzej; Kraszewski, Adam; Sobkowski, Michal.

Afiliação

Kolodziej K; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Romanowska J; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Stawinski J; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Boryski J; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Dabrowska A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Lipniacki A; National Institute of Medicines, Chelmska 30/34, 00-725 Warsaw, Poland.
Piasek A; National Institute of Medicines, Chelmska 30/34, 00-725 Warsaw, Poland.
Kraszewski A; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland. Electronic address: Adam.Kraszewski@ibch.poznan.pl.
Sobkowski M; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland. Electronic address: msob@ibch.poznan.pl.

Eur J Med Chem ; 100: 77-88, 2015 Jul 15.

Article em En | MEDLINE | ID: mdl-26071860

Assuntos

Fármacos Anti-HIV/farmacologia; Didesoxinucleosídeos/farmacologia; Fármacos Anti-HIV/síntese química; Fármacos Anti-HIV/química; Linhagem Celular; Sobrevivência Celular; Didesoxinucleosídeos/síntese química; Didesoxinucleosídeos/química; Relação Dose-Resposta a Droga; HIV-1/efeitos dos fármacos; Humanos; Interações Hidrofóbicas e Hidrofílicas; Testes de Sensibilidade Microbiana; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

2',3'-dideoxynucleosides; AZT; Anti-HIV; H-phosphonates; Heteroaryl amines; Lipophilicity; Phosphoramidates; Pro-nucleotides

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Didesoxinucleosídeos / Fármacos Anti-HIV Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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