Effect of electron radiation on vasomotor function of the left anterior descending coronary artery.
Life Sci Space Res (Amst)
; 4: 6-10, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-26072960
ABSTRACT
The left anterior descending (LAD, interventricular) coronary artery provides the blood supply to the mid-region of the heart and is a major site of vessel stenosis. Changes in LAD function can have major effects on heart function. In this report, we examined the effect of electron simulated solar particle event (eSPE) radiation on LAD function in a porcine animal model. Vasodilatory responses to adenosine diphosphate (ADP; 10(−9)10(−4) M), bradykinin (BK; 10(−11)10(−6) M), and sodium nitroprusside (SNP; 10(−10)10(−4) M) were assessed. The LAD arteries from Control (non-irradiated) and the eSPE (irradiated) animals were isolated and exhibited a similar relaxation response following treatment with either ADP or SNP. In contrast, a significantly reduced relaxation response to BK treatment was observed in the eSPE irradiated group, compared to the control group. These data demonstrate that simulated SPE radiation exposure alters LAD function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
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Bradicinina
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Nitroprussiato
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Fenômenos Fisiológicos Cardiovasculares
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Difosfato de Adenosina
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Vasos Coronários
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Coração
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article