New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII.
Bioorg Med Chem Lett
; 25(16): 3281-4, 2015 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-26073006
ABSTRACT
A series of 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides was synthesised and the activity of the new compounds as inhibitors of hCA I, II, IX, and XII was evaluated. These new derivatives exhibited some peculiarities with respect to previously reported sulfonamide based inhibitors of CA. We observed that the nature of the substituents in the position 3 and 4 of the dihydro-thiazole ring was relevant in determining both activity and selectivity profiles.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
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Tiazóis
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Anidrases Carbônicas
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Anidrase Carbônica I
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Anidrase Carbônica II
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article