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Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project.
Horvatovich, Péter; Lundberg, Emma K; Chen, Yu-Ju; Sung, Ting-Yi; He, Fuchu; Nice, Edouard C; Goode, Robert J; Yu, Simon; Ranganathan, Shoba; Baker, Mark S; Domont, Gilberto B; Velasquez, Erika; Li, Dong; Liu, Siqi; Wang, Quanhui; He, Qing-Yu; Menon, Rajasree; Guan, Yuanfang; Corrales, Fernando J; Segura, Victor; Casal, J Ignacio; Pascual-Montano, Alberto; Albar, Juan P; Fuentes, Manuel; Gonzalez-Gonzalez, Maria; Diez, Paula; Ibarrola, Nieves; Degano, Rosa M; Mohammed, Yassene; Borchers, Christoph H; Urbani, Andrea; Soggiu, Alessio; Yamamoto, Tadashi; Salekdeh, Ghasem Hosseini; Archakov, Alexander; Ponomarenko, Elena; Lisitsa, Andrey; Lichti, Cheryl F; Mostovenko, Ekaterina; Kroes, Roger A; Rezeli, Melinda; Végvári, Ákos; Fehniger, Thomas E; Bischoff, Rainer; Vizcaíno, Juan Antonio; Deutsch, Eric W; Lane, Lydie; Nilsson, Carol L; Marko-Varga, György; Omenn, Gilbert S.
Afiliação
  • Horvatovich P; Analytical Biochemistry, Department of Pharmacy, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Lundberg EK; Science for Life Laboratory, KTH - Royal Institute of Technology , SE-171 21 Stockholm, Sweden.
  • Chen YJ; Institute of Chemistry, Academia Sinica , 128 Academia Road Sec. 2, Taipei 115, Taiwan.
  • Sung TY; Institute of Information Science, Academia Sinica , 128 Academia Road Sec. 2, Taipei 115, Taiwan.
  • He F; The State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , No. 27 Taiping Road, Haidian District, Beijing 100850, China.
  • Nice EC; Department of Biochemistry and Molecular Biology, Monash University , Clayton, Victoria 3800, Australia.
  • Goode RJ; Department of Biochemistry and Molecular Biology, Monash University , Clayton, Victoria 3800, Australia.
  • Yu S; Department of Biochemistry and Molecular Biology, Monash University , Clayton, Victoria 3800, Australia.
  • Ranganathan S; Department of Chemistry and Biomolecular Sciences and ARC Centre of Excellence in Bioinformatics, Macquarie University , Sydney, New South Wales 2109, Australia.
  • Baker MS; Australian School of Advanced Medicine, Macquarie University , Sydney, NSW 2109, Australia.
  • Domont GB; Proteomics Unit, Institute of Chemistry, Federal University of Rio de Janeiro , Cidade Universitária, Av Athos da Silveira Ramos 149, CT-A542, 21941-909 Rio de Janeriro, Rj, Brazil.
  • Velasquez E; Proteomics Unit, Institute of Chemistry, Federal University of Rio de Janeiro , Cidade Universitária, Av Athos da Silveira Ramos 149, CT-A542, 21941-909 Rio de Janeriro, Rj, Brazil.
  • Li D; The State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , No. 27 Taiping Road, Haidian District, Beijing 100850, China.
  • Liu S; Beijing Institute of Genomics and BGI Shenzhen , No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China.
  • Wang Q; BGI Shenzhen , Beishan Road, Yantian District, Shenzhen, 518083, China.
  • He QY; Beijing Institute of Genomics and BGI Shenzhen , No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China.
  • Menon R; ■ Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University , Guangzhou 510632, China.
  • Guan Y; Department of Computational Medicine & Bioinformatics, University of Michigan , 100 Washtenaw Avenue, Ann Arbor, Michigan 48109-2218, United States.
  • Corrales FJ; Departments of Computational Medicine & Bioinformatics and Computer Sciences, University of Michigan , 100 Washtenaw Avenue, Ann Arbor, Michigan 48109-2218, United States.
  • Segura V; ProteoRed-ISCIII, Biomolecular and Bioinformatics Resources Platform (PRB2), Spanish Consortium of C-HPP (Chr-16), CIMA, University of Navarra, 31008 Pamplona, Spain.
  • Casal JI; Chr16 SpHPP Consortium , CIMA, University of Navarra, 31008 Pamplona, Spain.
  • Pascual-Montano A; ProteoRed-ISCIII, Biomolecular and Bioinformatics Resources Platform (PRB2), Spanish Consortium of C-HPP (Chr-16), CIMA, University of Navarra, 31008 Pamplona, Spain.
  • Albar JP; Chr16 SpHPP Consortium , CIMA, University of Navarra, 31008 Pamplona, Spain.
  • Fuentes M; Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas (CIB-CSIC) , 28040 Madrid, Spain.
  • Gonzalez-Gonzalez M; Centro Nacional de Biotecnologia (CNB-CSIC) , Cantoblanco, 28049 Madrid, Spain.
  • Diez P; Centro Nacional de Biotecnologia (CNB-CSIC) , Cantoblanco, 28049 Madrid, Spain.
  • Ibarrola N; Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
  • Degano RM; Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
  • Mohammed Y; Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
  • Borchers CH; Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
  • Urbani A; Cancer Research Center. Proteomics Unit and General Service of Cytometry, Department of Medicine, University of Salmanca-CSIC , IBSAL, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
  • Soggiu A; University of Victoria -Genome British Columbia Proteomics Centre, Vancouver Island Technology Park, #3101-4464 Markham Street, Victoria, British Columbia V8Z 7X8, Canada.
  • Yamamoto T; Center for Proteomics and Metabolomics, Leiden University Medical Center , 2333 ZA Leiden, The Netherlands.
  • Salekdeh GH; University of Victoria -Genome British Columbia Proteomics Centre, Vancouver Island Technology Park, #3101-4464 Markham Street, Victoria, British Columbia V8Z 7X8, Canada.
  • Archakov A; Proteomics and Metabonomic, Laboratory, Fondazione Santa Lucia , Rome, Italy.
  • Ponomarenko E; Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata" , Rome, Italy.
  • Lisitsa A; Department of Veterinary Science and Public Health (DIVET), University of Milano , via Celoria 10, 20133 Milano, Italy.
  • Lichti CF; Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University , Niigata, Japan.
  • Mostovenko E; Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
  • Kroes RA; Department of Systems Biology, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran.
  • Rezeli M; Orechovich Institute of Biomedical Chemistry , Moscow, Russia.
  • Végvári Á; Orechovich Institute of Biomedical Chemistry , Moscow, Russia.
  • Fehniger TE; Orechovich Institute of Biomedical Chemistry , Moscow, Russia.
  • Bischoff R; Department of Pharmacology and Toxicology, The University of Texas Medical Branch , Galveston, Texas 77555-0617, United States.
  • Vizcaíno JA; Department of Pharmacology and Toxicology, The University of Texas Medical Branch , Galveston, Texas 77555-0617, United States.
  • Deutsch EW; Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University , 1801 Maple Ave., Suite 4300, Evanston, Illinois 60201, United States.
  • Lane L; Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University , BMC D13, 221 84 Lund, Sweden.
  • Nilsson CL; Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University , BMC D13, 221 84 Lund, Sweden.
  • Marko-Varga G; Clinical Protein Science & Imaging, Department of Biomedical Engineering, Lund University , BMC D13, 221 84 Lund, Sweden.
  • Omenn GS; Analytical Biochemistry, Department of Pharmacy, University of Groningen , A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
J Proteome Res ; 14(9): 3415-31, 2015 Sep 04.
Article em En | MEDLINE | ID: mdl-26076068
ABSTRACT
This paper summarizes the recent activities of the Chromosome-Centric Human Proteome Project (C-HPP) consortium, which develops new technologies to identify yet-to-be annotated proteins (termed "missing proteins") in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification. The C-HPP also aims to identify new protein forms that may be caused by genetic variability, post-translational modifications, and alternative splicing. Proteogenomic data integration forms the basis of the C-HPP's activities; therefore, we have summarized some of the key approaches and their roles in the project. We present new analytical technologies that improve the chemical space and lower detection limits coupled to bioinformatics tools and some publicly available resources that can be used to improve data analysis or support the development of analytical assays. Most of this paper's content has been compiled from posters, slides, and discussions presented in the series of C-HPP workshops held during 2014. All data (posters, presentations) used are available at the C-HPP Wiki (http//c-hpp.webhosting.rug.nl/) and in the Supporting Information.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Mapeamento Cromossômico / Proteoma Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Mapeamento Cromossômico / Proteoma Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article