Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides.
PLoS One
; 10(6): e0130389, 2015.
Article
em En
| MEDLINE
| ID: mdl-26076445
ABSTRACT
Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases. This study aims to evaluate the effect of the cinnamon-derived molecule IND02 on the adhesion of leukocytes to host cells. The anti-inflammatory ability of IND02, a pentameric procyanidin type A polyphenol polymer isolated from cinnamon alcohol extract, was examined. Pretreatment with IND02 significantly reduced the attachment of THP-1 cells or neutrophils to TNF-α-activated HUVECs or E-selectin/ICAM-1, respectively. IND02 also reduced the binding of E-, L- and P-selectins with sialosides. Furthermore, IND02 could agglutinate human red blood cells (RBC), and the agglutination could be disrupted by sialylated glycoprotein. Our findings demonstrate that IND02, a cinnamon-derived compound, can interact with sialosides and block the binding of selectins and leukocytes with sialic acids.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adesão Celular
/
Cinnamomum zeylanicum
/
Proantocianidinas
/
Agregação Eritrocítica
/
Células Endoteliais da Veia Umbilical Humana
/
Neutrófilos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article