Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition.

An, Hanbing; Stoops, Sydney L; Deane, Natasha G; Zhu, Jing; Zi, Jinghuan; Weaver, Connie; Waterson, Alex G; Zijlstra, Andries; Lindsley, Craig W; Beauchamp, Robert Daniel

An, Hanbing; Stoops, Sydney L; Deane, Natasha G; Zhu, Jing; Zi, Jinghuan; Weaver, Connie; Waterson, Alex G; Zijlstra, Andries; Lindsley, Craig W; Beauchamp, Robert Daniel.

Afiliação

An H; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Stoops SL; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Deane NG; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Zhu J; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Zi J; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Weaver C; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Waterson AG; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Zijlstra A; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lindsley CW; Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Beauchamp RD; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Oncotarget ; 6(26): 22934-48, 2015 Sep 08.

Article em En | MEDLINE | ID: mdl-26082441

Assuntos

Transição Epitelial-Mesenquimal/efeitos dos fármacos; Isoxazóis/farmacologia; Neoplasias/tratamento farmacológico; Niacinamida/análogos & derivados; Bibliotecas de Moléculas Pequenas/farmacologia; Animais; Caderinas/genética; Linhagem Celular Tumoral; Embrião de Galinha; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Neoplasias Colorretais/patologia; Transição Epitelial-Mesenquimal/genética; Feminino; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Neoplasias Mamárias Experimentais/tratamento farmacológico; Neoplasias Mamárias Experimentais/genética; Neoplasias Mamárias Experimentais/patologia; Camundongos; Invasividade Neoplásica; Neoplasias/genética; Neoplasias/patologia; Niacinamida/farmacologia; Transcrição Gênica/efeitos dos fármacos

Palavras-chave

E-cadherin; EMT; small molecule

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Niacinamida / Bibliotecas de Moléculas Pequenas / Transição Epitelial-Mesenquimal / Isoxazóis / Neoplasias Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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