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The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence.
Trang, Tran Thi Huyen; Shiota, Seiji; Matsuda, Miyuki; Binh, Tran Thanh; Suzuki, Rumiko; Vilaichone, Ratha-korn; Mahachai, Varocha; Tshering, Lotay; Dung, Ho D Q; Uchida, Tomohisa; Matsunari, Osamu; Myint, Thein; Khien, Vu Van; Yamaoka, Yoshio.
Afiliação
  • Trang TT; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan ; Department of Molecular Biology, 108 Hospital, Hanoi, Vietnam.
  • Shiota S; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.
  • Matsuda M; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.
  • Binh TT; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan ; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam.
  • Suzuki R; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan.
  • Vilaichone RK; Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathum Thani 12120, Thailand.
  • Mahachai V; GI and Liver Center, Bangkok Medical Center, Bangkok 10310, Thailand.
  • Tshering L; Department of Surgery, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.
  • Dung HD; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam.
  • Uchida T; Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu 897-5593, Japan.
  • Matsunari O; Department of Gastroenterology, Oita University Faculty of Medicine, Yufu 879-5593, Japan.
  • Myint T; Department of Gastroenterology, Yangon General Hospital, Yangon 11131, Myanmar.
  • Khien VV; Department of Gastroenterology, 108 Hospital, Hanoi, Vietnam.
  • Yamaoka Y; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan ; Department of Medicine-Gastroenterology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Hou
Biomed Res Int ; 2015: 830813, 2015.
Article em En | MEDLINE | ID: mdl-26090448
Gastric cancer is a significant health problem in Asia. Although the prevalence of Helicobacter pylori infection is similar in Bhutan, Vietnam, and Myanmar, the incidence of gastric cancer is highest in Bhutan, followed by Vietnam and Myanmar. We hypothesized that H. pylori virulence factors contribute to the differences. The status of cagA, vacA, jhp0562, and ß-(1,3)galT(jhp0563) was examined in 371 H. pylori-infected patients from Bhutan, Vietnam, and Myanmar. Each virulence factor could not explain the difference of the incidence of gastric cancer. However, the prevalence of quadruple-positive for cagA, vacA s1, vacA m1, and jhp0562-positive/ß-(1,3)galT-negative was significantly higher in Bhutan than in Vietnam and Myanmar and correlated with gastric cancer incidence. Moreover, gastritis-staging scores measured by histology of gastric mucosa were significantly higher in quadruple-positive strains. We suggest that the cagA, vacA s1, vacA m1, and jhp0562-positive/ß-(1,3)galT-negative genotype may play a role in the development of gastric cancer.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Helicobacter pylori / Infecções por Helicobacter / Gastrite Tipo de estudo: Incidence_studies / Prevalence_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Helicobacter pylori / Infecções por Helicobacter / Gastrite Tipo de estudo: Incidence_studies / Prevalence_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article