Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen-Disparate Murine Model.

Zilberberg, Jenny; Matos, Jennifer; Dziopa, Eugenia; Dziopa, Leah; Yang, Zheng; Kirk, Christopher J; Assefnia, Shahin; Korngold, Robert

Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen-Disparate Murine Model.

Zilberberg, Jenny; Matos, Jennifer; Dziopa, Eugenia; Dziopa, Leah; Yang, Zheng; Kirk, Christopher J; Assefnia, Shahin; Korngold, Robert.

Afiliação

Zilberberg J; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey. Electronic address: jzilberberg@hackensackum.org.
Matos J; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
Dziopa E; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
Dziopa L; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
Yang Z; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.
Kirk CJ; Onyx Pharmaceuticals, South San Francisco, California.
Assefnia S; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC.
Korngold R; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey.

Biol Blood Marrow Transplant ; 21(9): 1555-64, 2015 Sep.

Article em En | MEDLINE | ID: mdl-26093043

Assuntos

Transplante de Medula Óssea; Doença Enxerto-Hospedeiro/tratamento farmacológico; Antígenos de Histocompatibilidade Menor/imunologia; Oligopeptídeos/farmacologia; Complexo de Endopeptidases do Proteassoma/imunologia; Linfócitos T/imunologia; Aloenxertos; Animais; Doença Enxerto-Hospedeiro/genética; Doença Enxerto-Hospedeiro/imunologia; Doença Enxerto-Hospedeiro/patologia; Interferon gama/genética; Interferon gama/imunologia; Camundongos; Camundongos Transgênicos; Antígenos de Histocompatibilidade Menor/genética; Complexo de Endopeptidases do Proteassoma/genética; Linfócitos T/patologia

Palavras-chave

BMT; GVHD; Immunoproteasome; Murine models

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Linfócitos T / Antígenos de Histocompatibilidade Menor / Transplante de Medula Óssea / Complexo de Endopeptidases do Proteassoma / Doença Enxerto-Hospedeiro Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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