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Hepatotoxicity mechanisms of isoniazid: A mini-review.
Hassan, Hozeifa M; Guo, Hong-Li; Yousef, Bashir A; Luyong, Zhang; Zhenzhou, Jiang.
Afiliação
  • Hassan HM; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.
  • Guo HL; Department of Pharmacology, Faculty of Pharmacy, University of Gezira, Wad-Medani, Sudan.
  • Yousef BA; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.
  • Luyong Z; Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.
  • Zhenzhou J; Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
J Appl Toxicol ; 35(12): 1427-32, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26095833
ABSTRACT
Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH-induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Hepática Induzida por Substâncias e Drogas / Isoniazida / Antituberculosos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Hepática Induzida por Substâncias e Drogas / Isoniazida / Antituberculosos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article