Selenium protects cerebral cells by cisplatin induced neurotoxicity.
Acta Cir Bras
; 30(6): 394-400, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26108027
ABSTRACT
PURPOSE:
To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium.METHODS:
Twenty-one male Wistar albino rats were divided into three groups control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, CSE group received 3mg/kg/day (twice-a-day as 1.5 mg/kg) selenium via oral gavage five days before cisplatin injection and continued for 11 consecutive days. The same volumes of saline were administered to C group intraperitoneally and orally at same time.RESULTS:
Heterochromatic and vacuolated neurons and dilated capillary vessels in the brain were observed in the histochemical examinations of cisplatin treated group. Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect. In addition, cytoplasmic staining of the cell for bcl-2, both cytoplasmic and nuclear staining for bax were determined to be positive in the all groups. Bax positive cells were increased in the CS group compared to C group, in contrast to decreased bcl-2 positivity.CONCLUSION:
Selenium limited apototic activity and histological changes due to the cisplatin related central neurotoxicity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Encéfalo
/
Cisplatino
/
Neurônios
/
Antineoplásicos
/
Antioxidantes
Tipo de estudo:
Evaluation_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article