Randomised controlled trial of topical kanuka honey for the treatment of rosacea.
BMJ Open
; 5(6): e007651, 2015 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-26109117
ABSTRACT
OBJECTIVE:
To investigate the efficacy of topical 90% medical-grade kanuka honey and 10% glycerine (Honevo) as a treatment for rosacea.DESIGN:
Randomised controlled trial with blinded assessment of primary outcome variable.SETTING:
Outpatient primary healthcare population from 5 New Zealand sites.PARTICIPANTS:
138 adults aged ≥ 16, with a diagnosis of rosacea, and a baseline blinded Investigator Global Assessment of Rosacea Severity Score (IGA-RSS) of ≥ 2. 69 participants were randomised to each treatment arm. 1 participant was excluded from the Honevo group, and 7 and 15 participants withdrew from the Honevo and control groups, respectively.INTERVENTIONS:
Participants were randomly allocated 11 to Honevo or control cream (Cetomacrogol), applied twice daily for 8 weeks. MAIN OUTCOMEMEASURES:
The primary outcome measure was the proportion of participants who had a ≥ 2 improvement in the 7-point IGA-RSS at week 8 compared to baseline. Secondary outcomes included change in IGA-RSS and subject-rated visual analogue score of change in severity (VAS-CS) on a 100 mm scale (0 mm 'much worse', 100 mm 'much improved') at weeks 2 and 8.RESULTS:
24/68 (34.3%) in the Honevo group and 12/69 (17.4%) in the control group had a ≥ 2 improvement in IGA-RSS at week 8 compared to baseline (relative risk 2.03; 95% CI 1.11 to 3.72, p=0.020). The change in IGA-RSS for Honevo compared to control at week 2 minus baseline was -1 (Hodges-Lehman estimate, 95% CI -1 to 0, p=0.03), and at week 8 minus baseline was -1 (Hodges-Lehman estimate, 95% CI -1 to 0, p=0.005). The VAS-CS at week 2 was 9.1 (95% CI 3.5 to 14.7), p=0.002, and at week 8 was 12.3 (95% CI 5.7 to 18.9)¸ p<0.001 for Honevo compared to control.CONCLUSIONS:
Honevo is an effective treatment for rosacea. TRIAL REGISTRATION NUMBER This trial was registered in the Australian and New Zealand Clinical Trials Registry ACTRN12614000004662.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rosácea
/
Kunzea
/
Mel
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article