Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of &#945;-SMA and collagen III.

Zhou, De-Jiang; Mu, Dong; Jiang, Ming-De; Zheng, Shu-Mei; Zhang, Yong; He, Sheng; Weng, Min; Zeng, Wei-Zheng

Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of α-SMA and collagen III.

Zhou, De-Jiang; Mu, Dong; Jiang, Ming-De; Zheng, Shu-Mei; Zhang, Yong; He, Sheng; Weng, Min; Zeng, Wei-Zheng.

Afiliação

Zhou DJ; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.
Mu D; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.
Jiang MD; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.
Zheng SM; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.
Zhang Y; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.
He S; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.
Weng M; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.
Zeng WZ; Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.

Mol Med Rep ; 12(3): 4095-4102, 2015 Sep.

Article em En | MEDLINE | ID: mdl-26126609

Assuntos

Actinas/metabolismo; Antioxidantes/metabolismo; Colágeno Tipo III/metabolismo; Dimetilnitrosamina/toxicidade; Cirrose Hepática Experimental/prevenção & controle; Naftoquinonas/farmacologia; Substâncias Protetoras/farmacologia; Actinas/genética; Animais; Colágeno Tipo III/genética; Células Estreladas do Fígado/citologia; Células Estreladas do Fígado/metabolismo; Imuno-Histoquímica; Fígado/efeitos dos fármacos; Fígado/metabolismo; Fígado/patologia; Cirrose Hepática Experimental/induzido quimicamente; Cirrose Hepática Experimental/patologia; Masculino; Malondialdeído/metabolismo; PPAR gama/genética; PPAR gama/metabolismo; Ratos; Ratos Sprague-Dawley; Superóxido Dismutase/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinas / Naftoquinonas / Substâncias Protetoras / Colágeno Tipo III / Dimetilnitrosamina / Cirrose Hepática Experimental / Antioxidantes Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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