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WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
Friedel, Perrine; Kahle, Kristopher T; Zhang, Jinwei; Hertz, Nicholas; Pisella, Lucie I; Buhler, Emmanuelle; Schaller, Fabienne; Duan, JingJing; Khanna, Arjun R; Bishop, Paul N; Shokat, Kevan M; Medina, Igor.
Afiliação
  • Friedel P; Institut de Neurobiologie de la Méditerranée (INMED), INSERM Unité 901, 13273 Marseille, France. Aix-Marseille Université, UMR 901, 13273 Marseille, France.
  • Kahle KT; Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. kkahle@enders.tch.harvard.edu igor.medyna@inserm.fr.
  • Zhang J; UK Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
  • Hertz N; Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143-0450, USA.
  • Pisella LI; Institut de Neurobiologie de la Méditerranée (INMED), INSERM Unité 901, 13273 Marseille, France. Aix-Marseille Université, UMR 901, 13273 Marseille, France.
  • Buhler E; Aix-Marseille Université, UMR 901, 13273 Marseille, France. Plateforme Post-Génomique, INMED, 13273 Marseille, France.
  • Schaller F; Aix-Marseille Université, UMR 901, 13273 Marseille, France. Plateforme Post-Génomique, INMED, 13273 Marseille, France.
  • Duan J; Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Khanna AR; Department of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Bishop PN; School of Biochemistry, University of Bristol, Bristol BS8 1TH, UK.
  • Shokat KM; Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143-0450, USA.
  • Medina I; Institut de Neurobiologie de la Méditerranée (INMED), INSERM Unité 901, 13273 Marseille, France. Aix-Marseille Université, UMR 901, 13273 Marseille, France. kkahle@enders.tch.harvard.edu igor.medyna@inserm.fr.
Sci Signal ; 8(383): ra65, 2015 Jun 30.
Article em En | MEDLINE | ID: mdl-26126716
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Simportadores / Peptídeos e Proteínas de Sinalização Intracelular / Ácido gama-Aminobutírico / Potenciais da Membrana / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Simportadores / Peptídeos e Proteínas de Sinalização Intracelular / Ácido gama-Aminobutírico / Potenciais da Membrana / Neurônios Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article