Blood B Cell and Regulatory Subset Content in Multiple Sclerosis Patients.
J Mult Scler (Foster City)
; 2(2)2015 May.
Article
em En
| MEDLINE
| ID: mdl-26137596
ABSTRACT
OBJECTIVE:
B cell targeted therapies have been effective in slowing multiple sclerosis (MS) disease progression suggesting a direct causal link for this lymphoid subset. A small subset of B cells with regulative properties (Bregs) exists in peripheral blood, and induction of Bregs ameliorates experimental autoimmune encephalomyelitis (EAE), the murine model for MS. Therefore the frequency of B cell subsets and regulatory B cells in particular in peripheral blood of MS patients is of interest.METHODS:
The phenotype and frequency of B cell subsets in peripheral blood from 32 MS patients and 34 healthy controls (HC) were examined using flow cytometry.RESULTS:
We found that there is an increase in CD19+ cell number in MS 1347 ± 159 cells/µL, (average ± SEM) compared to HC, 935 ± 129 cells/µL and no apparent deficiency in B-cells with a regulatory phenotype. In addition, we observed a loss of correlation between CD19+ B cells and total lymphocyte count in MS.CONCLUSION:
These findings suggest altered blood B-cell homeostasis in MS patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article