Fibril growth and seeding capacity play key roles in &#945;-synuclein-mediated apoptotic cell death.

Mahul-Mellier, A-L; Vercruysse, F; Maco, B; Ait-Bouziad, N; De Roo, M; Muller, D; Lashuel, H A

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.

Mahul-Mellier, A-L; Vercruysse, F; Maco, B; Ait-Bouziad, N; De Roo, M; Muller, D; Lashuel, H A.

Afiliação

Mahul-Mellier AL; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Vercruysse F; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Maco B; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
Ait-Bouziad N; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
De Roo M; Département des Neurosciences Fondamentales, Université de Genève, Faculté de Médecine, Centre Médical Universitaire, 1211 Genève 4, Switzerland.
Muller D; Département des Neurosciences Fondamentales, Université de Genève, Faculté de Médecine, Centre Médical Universitaire, 1211 Genève 4, Switzerland.
Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.

Cell Death Differ ; 22(12): 2107-22, 2015 Dec.

Article em En | MEDLINE | ID: mdl-26138444

Assuntos

Apoptose; alfa-Sinucleína/metabolismo; Animais; Caspase 3/metabolismo; Caspase 8/metabolismo; Caspase 9/metabolismo; Células Cultivadas; Hipocampo/citologia; Hipocampo/metabolismo; Humanos; Imuno-Histoquímica; Camundongos; Camundongos Endogâmicos C57BL; Microscopia Eletrônica de Transmissão; Proteínas Recombinantes/biossíntese; Proteínas Recombinantes/química; Proteínas Recombinantes/isolamento & purificação; alfa-Sinucleína/química; alfa-Sinucleína/genética; Proteínas tau/genética; Proteínas tau/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Alfa-Sinucleína Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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