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Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.
Kang, Hee-Bum; Fan, Jun; Lin, Ruiting; Elf, Shannon; Ji, Quanjiang; Zhao, Liang; Jin, Lingtao; Seo, Jae Ho; Shan, Changliang; Arbiser, Jack L; Cohen, Cynthia; Brat, Daniel; Miziorko, Henry M; Kim, Eunhee; Abdel-Wahab, Omar; Merghoub, Taha; Fröhling, Stefan; Scholl, Claudia; Tamayo, Pablo; Barbie, David A; Zhou, Lu; Pollack, Brian P; Fisher, Kevin; Kudchadkar, Ragini R; Lawson, David H; Sica, Gabriel; Rossi, Michael; Lonial, Sagar; Khoury, Hanna J; Khuri, Fadlo R; Lee, Benjamin H; Boggon, Titus J; He, Chuan; Kang, Sumin; Chen, Jing.
Afiliação
  • Kang HB; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Fan J; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Lin R; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Elf S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Ji Q; Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA.
  • Zhao L; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Jin L; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Seo JH; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Shan C; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Arbiser JL; Department of Dermatology, Emory University, Atlanta, Georgia 30322, USA.
  • Cohen C; Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA.
  • Brat D; Department of Pathology and Laboratory Medicine.
  • Miziorko HM; Department of Pathology and Laboratory Medicine.
  • Kim E; Division of Molecular Biology and Biochemistry, University of Missouri, Kansas City, MO 64110, USA.
  • Abdel-Wahab O; Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  • Merghoub T; Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  • Fröhling S; Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  • Scholl C; Department of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Section for Personalized Oncology, Heidelberg University Hospital, German Cancer Consortium (DKTK), 69121 Heidelberg, Germany.
  • Tamayo P; Department of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
  • Barbie DA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Zhou L; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Pollack BP; School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Fisher K; Department of Dermatology, Emory University, Atlanta, Georgia 30322, USA.
  • Kudchadkar RR; Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA.
  • Lawson DH; Department of Pathology and Laboratory Medicine.
  • Sica G; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Rossi M; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Lonial S; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Khoury HJ; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Khuri FR; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Lee BH; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • Boggon TJ; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
  • He C; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA.
  • Kang S; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
  • Chen J; Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA.
Mol Cell ; 59(3): 345-358, 2015 Aug 06.
Article em En | MEDLINE | ID: mdl-26145173
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Leucemia de Células Pilosas / Proteínas Proto-Oncogênicas B-raf / MAP Quinase Quinase 1 / Fator 1 de Transcrição de Octâmero / Oxo-Ácido-Liases / Melanoma Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Leucemia de Células Pilosas / Proteínas Proto-Oncogênicas B-raf / MAP Quinase Quinase 1 / Fator 1 de Transcrição de Octâmero / Oxo-Ácido-Liases / Melanoma Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article