MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP.

Zhang, Xin; Schulz, Ramona; Edmunds, Shelley; Krüger, Elke; Markert, Elke; Gaedcke, Jochen; Cormet-Boyaka, Estelle; Ghadimi, Michael; Beissbarth, Tim; Levine, Arnold J; Moll, Ute M; Dobbelstein, Matthias

Zhang, Xin; Schulz, Ramona; Edmunds, Shelley; Krüger, Elke; Markert, Elke; Gaedcke, Jochen; Cormet-Boyaka, Estelle; Ghadimi, Michael; Beissbarth, Tim; Levine, Arnold J; Moll, Ute M; Dobbelstein, Matthias.

Afiliação

Zhang X; Institute of Molecular Oncology, University Medical Center Göttingen, 37077 Göttingen, Germany.
Schulz R; Institute of Molecular Oncology, University Medical Center Göttingen, 37077 Göttingen, Germany.
Edmunds S; Institute of Molecular Oncology, University Medical Center Göttingen, 37077 Göttingen, Germany.
Krüger E; Institut für Biochemie, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Markert E; Cancer Research UK Beatson Institute, Glasgow, G61 1BD Scotland, UK.
Gaedcke J; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany.
Cormet-Boyaka E; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Ghadimi M; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany.
Beissbarth T; Department of Medical Statistics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Levine AJ; Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA.
Moll UM; Institute of Molecular Oncology, University Medical Center Göttingen, 37077 Göttingen, Germany; Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.
Dobbelstein M; Institute of Molecular Oncology, University Medical Center Göttingen, 37077 Göttingen, Germany. Electronic address: mdobbel@gwdg.de.

Mol Cell ; 59(2): 243-57, 2015 Jul 16.

Article em En | MEDLINE | ID: mdl-26145175

Assuntos

MicroRNAs/genética; MicroRNAs/metabolismo; Chaperonas Moleculares/genética; Chaperonas Moleculares/metabolismo; Inibidores de Proteassoma/metabolismo; Regiões 3' não Traduzidas; Animais; Apoptose; Ácidos Borônicos/farmacologia; Bortezomib; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Pontos de Checagem do Ciclo Celular; Linhagem Celular Tumoral; Proliferação de Células; Proteínas Inibidoras de Quinase Dependente de Ciclina/metabolismo; Resistencia a Medicamentos Antineoplásicos/genética; Receptor alfa de Estrogênio/metabolismo; Feminino; Técnicas de Silenciamento de Genes; Células HCT116; Células Hep G2; Humanos; Células MCF-7; Camundongos; Chaperonas Moleculares/antagonistas & inibidores; Complexo de Endopeptidases do Proteassoma/metabolismo; Inibidores de Proteassoma/farmacologia; Pirazinas/farmacologia; RNA Interferente Pequeno/genética; Proteína Supressora de Tumor p53/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chaperonas Moleculares / MicroRNAs / Inibidores de Proteassoma Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google