Effects of moderate- and high-intensity chronic exercise on brain-derived neurotrophic factor expression in fast and slow muscles.
Muscle Nerve
; 53(3): 446-51, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26148339
ABSTRACT
INTRODUCTION:
Brain-derived neurotrophic factor (BDNF) protein expression is sensitive to cellular activity. In the sedentary state, BDNF expression is affected by the muscle phenotype.METHODS:
Eighteen Wistar rats were divided into the following 3 groups sedentary (S); moderate-intensity training (MIT); and high-intensity training (HIT). The training protocol lasted 8 weeks. Forty-eight hours after training, total RNA and protein levels in the soleus and plantaris muscles were obtained.RESULTS:
In the plantaris, the BDNF protein level was lower in the HIT than in the S group (P < 0.05). A similar effect was found in the soleus (without significant difference). In the soleus, higher Bdnf mRNA levels were found in the HIT group (P < 0.001 vs. S and MIT groups). In the plantaris muscle, similar Bdnf mRNA levels were found in all groups.CONCLUSIONS:
These results indicate that high-intensity chronic exercise reduces BDNF protein level in fast muscles and increases Bdnf mRNA levels in slow muscles.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Resistência Física
/
Regulação da Expressão Gênica
/
Músculo Esquelético
/
Fator Neurotrófico Derivado do Encéfalo
/
Contração Muscular
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article