An open-source computational and data resource to analyze digital maps of immunopeptidomes.
Elife
; 42015 Jul 08.
Article
em En
| MEDLINE
| ID: mdl-26154972
ABSTRACT
We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources by SWATH mass spectrometry (MS). This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the design of efficient immunotherapies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Bases de Dados Factuais
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Biologia Computacional
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Antígenos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article