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MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.
Ohnmacht, Caspar; Park, Joo-Hong; Cording, Sascha; Wing, James B; Atarashi, Koji; Obata, Yuuki; Gaboriau-Routhiau, Valérie; Marques, Rute; Dulauroy, Sophie; Fedoseeva, Maria; Busslinger, Meinrad; Cerf-Bensussan, Nadine; Boneca, Ivo G; Voehringer, David; Hase, Koji; Honda, Kenya; Sakaguchi, Shimon; Eberl, Gérard.
Afiliação
  • Ohnmacht C; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
  • Park JH; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
  • Cording S; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
  • Wing JB; Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan.
  • Atarashi K; RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan. PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.
  • Obata Y; The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
  • Gaboriau-Routhiau V; INSERM, U1163, Laboratory of Intestinal Immunity, Paris, France. Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France. INRA Micalis UMR1319, Jouy-en-Josas, France.
  • Marques R; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
  • Dulauroy S; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
  • Fedoseeva M; Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Zentrum München, Munich, Germany.
  • Busslinger M; Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria.
  • Cerf-Bensussan N; INSERM, U1163, Laboratory of Intestinal Immunity, Paris, France. Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France.
  • Boneca IG; Institut Pasteur, Biology and Genetics of Bacterial Cell Wall, 75724 Paris, France. INSERM, Groupe Avenir, 75015 Paris, France.
  • Voehringer D; Department of Infection Biology at the Institute of Clinical Microbiology, Immunology and Hygiene, University Clinic Erlangen and Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
  • Hase K; The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
  • Honda K; RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan. CREST, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.
  • Sakaguchi S; Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  • Eberl G; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France. gerard.eberl@pasteur.fr.
Science ; 349(6251): 989-93, 2015 Aug 28.
Article em En | MEDLINE | ID: mdl-26160380
ABSTRACT
Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T(H)17) cells and regulatory T cells (T(regs)) in the intestine. Here, we report that microbiota-induced T(regs) express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to T(H)17 cells. In the absence of RORγt(+) T(regs), T(H)2-driven defense against helminths is more efficient, whereas T(H)2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3 RORγt(+) T(regs) and T(H)17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Imunidade nas Mucosas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Microbiota / Mucosa Intestinal / Intestinos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Imunidade nas Mucosas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Microbiota / Mucosa Intestinal / Intestinos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article