Dry powder pulmonary delivery of cationic PGA-co-PDL nanoparticles with surface adsorbed model protein.

Kunda, Nitesh K; Alfagih, Iman M; Dennison, Sarah R; Somavarapu, Satyanarayana; Merchant, Zahra; Hutcheon, Gillian A; Saleem, Imran Y

Kunda, Nitesh K; Alfagih, Iman M; Dennison, Sarah R; Somavarapu, Satyanarayana; Merchant, Zahra; Hutcheon, Gillian A; Saleem, Imran Y.

Afiliação

Kunda NK; Formulation and Drug Delivery Research, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Alfagih IM; Formulation and Drug Delivery Research, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom; Department of Pharmaceutics, College of Pharmacy, King Saud University, Saudi Arabia.
Dennison SR; Research and Innovation, University of Central Lancashire, Preston, United Kingdom.
Somavarapu S; Department of Pharmaceutics, School of Pharmacy, University College London, London, United Kingdom.
Merchant Z; Department of Pharmaceutics, School of Pharmacy, University College London, London, United Kingdom.
Hutcheon GA; Formulation and Drug Delivery Research, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
Saleem IY; Formulation and Drug Delivery Research, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom. Electronic address: I.Saleem@ljmu.ac.uk.

Int J Pharm ; 492(1-2): 213-22, 2015 Aug 15.

Article em En | MEDLINE | ID: mdl-26169146

Assuntos

Nanopartículas/química; Poliésteres/química; Soroalbumina Bovina/química; Administração por Inalação; Adsorção; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Dicroísmo Circular; Liberação Controlada de Fármacos; Eletroforese em Gel de Poliacrilamida; Humanos; Microscopia Eletrônica de Transmissão; Nanopartículas/administração & dosagem; Nanopartículas/ultraestrutura; Poliésteres/administração & dosagem; Pós; Estabilidade Proteica; Compostos de Amônio Quaternário/química; Soroalbumina Bovina/administração & dosagem; Propriedades de Superfície; Tensoativos/química

Palavras-chave

Dry powder inhalation; Nanoparticles; Proteins; Pulmonary delivery; Spray drying

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliésteres / Soroalbumina Bovina / Nanopartículas Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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