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Sulfamethoxazole susceptibility of Mycobacterium tuberculosis isolates from HIV-infected Ugandan adults with tuberculosis taking trimethoprim-sulfamethoxazole prophylaxis.
Ogwang, Sam; Good, Caryn E; Okware, Brenda; Nsereko, Mary; Jacobs, Michael R; Boom, W Henry; Bark, Charles M.
Afiliação
  • Ogwang S; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda Joint Clinical Research Centre, Kampala, Uganda.
  • Good CE; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Okware B; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.
  • Nsereko M; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.
  • Jacobs MR; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Boom WH; Tuberculosis Research Unit, Case Western Reserve University, Cleveland, Ohio, USA.
  • Bark CM; Tuberculosis Research Unit, Case Western Reserve University, Cleveland, Ohio, USA MetroHealth Medical Center, Cleveland, Ohio, USA cmb148@case.edu.
Antimicrob Agents Chemother ; 59(9): 5844-6, 2015 Sep.
Article em En | MEDLINE | ID: mdl-26169400
ABSTRACT
Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patients in sub-Saharan Africa. Thirty-eight of 40 Mycobacterium tuberculosis isolates (95%) from pretreatment sputum samples from Ugandan adults with pulmonary TB, including HIV-infected patients taking trimethoprim-sulfamethoxazole prophylaxis, were susceptible with MICs of ≤38.4 µg/ml.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Infecções por HIV / Combinação Trimetoprima e Sulfametoxazol / Mycobacterium tuberculosis / Antituberculosos Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Infecções por HIV / Combinação Trimetoprima e Sulfametoxazol / Mycobacterium tuberculosis / Antituberculosos Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article