Endoscopic ultrasound-guided liver biopsy: a multicenter experience.
Endosc Int Open
; 3(3): E210-5, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26171433
ABSTRACT
BACKGROUND AND AIMS:
Endoscopic ultrasound-guided (EUS) liver biopsy (LB) is proposed as a newer method that offers several advantages over existing techniques for sampling liver tissue. This study evaluated the diagnostic yield of EUS-LB as the primary outcome measure. In addition, the safety of the technique in a large patient cohort was assessed. PATIENTS ANDMETHODS:
Patients undergoing EUS for evaluation of elevated liver enzymes or hepatic disease were included in this prospective, non-randomized, multicenter study. EUS-LB was performed with EUS-fine needle aspiration (FNA; 19-gauge needle). Tissue was formalin-fixed and stained with hematoxylin and eosin, and trichrome. Using a microscope micrometer, specimen length was measured and the number of complete portal triads (CPTs) were counted. The main outcome measure was to assess the diagnostic yield of EUS-LB, and to monitor for any procedure-related complications.RESULTS:
Patients (110; median age, 53 years; 62 women) underwent EUS-LB at eight centers. The indication was abnormal liver enzymes in 96 patients. LB specimens sufficient for pathological diagnosis were obtained in 108 of 110 patients (98â%). The overall tissue yield from 110 patients was a median aggregate length of 38âmm (range, 0â-â203), with median of 14 CPTs (range, 0â-â68). There was no statistical difference in the yield between bilobar, left lobe only, or right lobe only biopsies. There was one complication (0.9â%) where self-limited bleeding occurred in a coagulopathic and thrombocytopenic patient. This complication was managed conservatively.CONCLUSIONS:
EUS-guided LB was a safe technique that yields tissue adequate for diagnosis among 98â% of patients evaluated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article