Epithelia migration: a spatiotemporal interplay between contraction and adhesion.
Cell Adh Migr
; 9(5): 340-4, 2015.
Article
em En
| MEDLINE
| ID: mdl-26176587
ABSTRACT
Epithelial tissues represent 60% of the cells that form the human body and where more than 90% of all cancers derived. Epithelia transformation and migration involve altered cell contractile mechanics powered by an actomyosin-based cytoskeleton and influenced by cell-cell and cell-extracellular matrix interactions. A balance between contractile and adhesive forces regulates a large number of cellular and tissue properties crucial for epithelia migration and tumorigenesis. In this review, the forces driving normal epithelia transformation into highly motile and invasive cells and tissues will be discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Transformação Celular Neoplásica
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article