Asymmetric Total Synthesis of Propindilactone G.
J Am Chem Soc
; 137(32): 10120-3, 2015 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-26181605
ABSTRACT
A concise total synthesis of (+)-propindilactone G, a nortriterpenoid isolated from the stems of Schisandra propinqua var. propinqua, has been achieved for the first time. The key steps of the synthesis include an asymmetric Diels-Alder reaction, a Pauson-Khand reaction, a Pd-catalyzed reductive hydrogenolysis reaction, and an oxidative heterocoupling reaction. These reactions enabled the synthesis of (+)-propindilactone G in only 20 steps. As a consequence of our synthetic studies, the structure of (+)-propindilactone G has been revised.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article