RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response.

Meijering, Roelien A M; Wiersma, Marit; van Marion, Denise M S; Zhang, Deli; Hoogstra-Berends, Femke; Dijkhuis, Anne-Jan; Schmidt, Martina; Wieland, Thomas; Kampinga, Harm H; Henning, Robert H; Brundel, Bianca J J M

Meijering, Roelien A M; Wiersma, Marit; van Marion, Denise M S; Zhang, Deli; Hoogstra-Berends, Femke; Dijkhuis, Anne-Jan; Schmidt, Martina; Wieland, Thomas; Kampinga, Harm H; Henning, Robert H; Brundel, Bianca J J M.

Afiliação

Meijering RA; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wiersma M; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van Marion DM; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Zhang D; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hoogstra-Berends F; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dijkhuis AJ; Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Schmidt M; Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
Wieland T; Institute of Experimental and Clinical Pharmacology and Toxicology, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Kampinga HH; Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Henning RH; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Brundel BJ; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.

PLoS One ; 10(7): e0133553, 2015.

Article em En | MEDLINE | ID: mdl-26193369

Assuntos

Proteínas de Ligação a DNA/metabolismo; Proteínas de Choque Térmico HSP70/metabolismo; Temperatura Alta; Fatores de Transcrição/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo; Animais; Apoptose/efeitos dos fármacos; Western Blotting; Caspase 3/metabolismo; Linhagem Celular Tumoral; Proteínas de Ligação a DNA/genética; Dipeptídeos/farmacologia; Fator de Iniciação 2 em Eucariotos/metabolismo; Regulação da Expressão Gênica; Células HEK293; Proteínas de Choque Térmico HSP70/genética; Fatores de Transcrição de Choque Térmico; Humanos; Microscopia Confocal; Fosforilação/efeitos dos fármacos; Regiões Promotoras Genéticas/genética; Ligação Proteica; Elementos de Resposta/genética; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Fatores de Transcrição/genética; Proteína rhoA de Ligação ao GTP/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas de Choque Térmico HSP70 / Proteína rhoA de Ligação ao GTP / Proteínas de Ligação a DNA / Temperatura Alta Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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