Use of Medications with Anticholinergic Activity and Self-Reported Injurious Falls in Older Community-Dwelling Adults.
J Am Geriatr Soc
; 63(8): 1561-9, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26200894
ABSTRACT
OBJECTIVES:
To assess the association between the use of medications with anticholinergic activity and the subsequent risk of injurious falls in older adults.DESIGN:
Prospective, population-based study using data from The Irish Longitudinal Study on Ageing.SETTING:
Irish population.PARTICIPANTS:
Community-dwelling men and women without dementia aged 65 and older (N = 2,696). MEASUREMENTS Self-reported injurious falls reported once approximately 2 years after baseline interview. Self-reported regular medication use at baseline interview. Pharmacy dispensing records from the Irish Health Service Executive Primary Care Reimbursement Service in a subset (n = 1,553).RESULTS:
Nine percent of men and 17% of women reported injurious falls. In men, the use of medications with definite anticholinergic activity was associated with greater risk of subsequent injurious falls (adjusted relative risk (aRR) = 2.55, 95% confidence interval (CI) = 1.33-4.88), but the risk of having any fall and the number of falls reported were not significantly greater. Greater anticholinergic burden was associated with greater injurious falls risk. No associations were observed for women. Findings were similar using pharmacy dispensing records. The aRR for medications with definite anticholinergic activity dispensed in the month before baseline and subsequent injurious falls in men was 2.53 (95% CI = 1.15-5.54).CONCLUSION:
The regular use of medications with anticholinergic activity is associated with subsequent injurious falls in older men, although falls were self-reported after a 2-year recall and so may have been underreported. Further research is required to validate this finding in men and to consider the effect of duration and dose of anticholinergic medications.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ferimentos e Lesões
/
Acidentes por Quedas
/
Envelhecimento
/
Avaliação Geriátrica
/
Antagonistas Colinérgicos
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Demência
/
Autorrelato
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
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Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article