Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines.

Hanes, Melinda S; Salanga, Catherina L; Chowdry, Arnab B; Comerford, Iain; McColl, Shaun R; Kufareva, Irina; Handel, Tracy M

Hanes, Melinda S; Salanga, Catherina L; Chowdry, Arnab B; Comerford, Iain; McColl, Shaun R; Kufareva, Irina; Handel, Tracy M.

Afiliação

Hanes MS; From the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 and.
Salanga CL; From the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 and.
Chowdry AB; From the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 and.
Comerford I; Chemokine Biology Group, The School of Molecular and Biomedical Science, The University of Adelaide, North Terrace Campus, Adelaide, South Australia 5005, Australia.
McColl SR; Chemokine Biology Group, The School of Molecular and Biomedical Science, The University of Adelaide, North Terrace Campus, Adelaide, South Australia 5005, Australia.
Kufareva I; From the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 and.
Handel TM; From the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093 and thandel@ucsd.edu.

J Biol Chem ; 290(37): 22385-97, 2015 Sep 11.

Article em En | MEDLINE | ID: mdl-26216880

Assuntos

Quimiocina CXCL12/química; Modelos Moleculares; Biblioteca de Peptídeos; Receptores CXCR4/química; Receptores CXCR/química; Animais; Quimiocina CXCL12/genética; Quimiocina CXCL12/farmacologia; Modelos Animais de Doenças; Células HEK293; Humanos; Células Jurkat; Camundongos; Esclerose Múltipla/tratamento farmacológico; Esclerose Múltipla/genética; Esclerose Múltipla/metabolismo; Esclerose Múltipla/patologia; Engenharia de Proteínas; Receptores CXCR/genética; Receptores CXCR4/genética

Palavras-chave

ACKR3; C-X-C chemokine receptor type 4 (CXCR-4); CXCL12; G protein-coupled receptor (GPCR); SDF-1a; chemokine; chemokine receptors; experimental autoimmune encephalomyelitis (EAE); phage display; signaling

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Modelos Moleculares / Biblioteca de Peptídeos / Receptores CXCR4 / Quimiocina CXCL12 / Receptores CXCR Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google