Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study.

Kadayat, Tara Man; Song, Chanju; Kwon, Youngjoo; Lee, Eung-Seok

Kadayat, Tara Man; Song, Chanju; Kwon, Youngjoo; Lee, Eung-Seok.

Afiliação

Kadayat TM; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Song C; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of Korea.
Kwon Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: ykwon@ewha.ac.kr.
Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: eslee@yu.ac.kr.

Bioorg Chem ; 62: 30-40, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26218799

Assuntos

Antineoplásicos/uso terapêutico; Indenos/síntese química; Indenos/farmacologia; Piridinas/síntese química; Piridinas/farmacologia; Relação Estrutura-Atividade; Inibidores da Topoisomerase I/uso terapêutico; Inibidores da Topoisomerase II/uso terapêutico; Camptotecina/farmacologia; Etoposídeo/farmacologia; Células HeLa; Humanos

Palavras-chave

2,4-Diaryl-5H-indeno[1,2-b]pyridines; Anticancer agents; Chlorine group substitution; Cytotoxicity; Hydroxyl group; Topoisomerase I and II inhibition

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Relação Estrutura-Atividade / Inibidores da Topoisomerase I / Inibidores da Topoisomerase II / Indenos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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