Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.

Mochizuki-Kashio, Makiko; Aoyama, Kazumasa; Sashida, Goro; Oshima, Motohiko; Tomioka, Takahisa; Muto, Tomoya; Wang, Changshan; Iwama, Atsushi

Mochizuki-Kashio, Makiko; Aoyama, Kazumasa; Sashida, Goro; Oshima, Motohiko; Tomioka, Takahisa; Muto, Tomoya; Wang, Changshan; Iwama, Atsushi.

Afiliação

Mochizuki-Kashio M; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;
Aoyama K; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;
Sashida G; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan;
Oshima M; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;
Tomioka T; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan; and.
Muto T; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;
Wang C; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan; College of Life Sciences, Inner Mongolia University, Hohhot, China.
Iwama A; Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan;

Blood ; 126(10): 1172-83, 2015 Sep 03.

Article em En | MEDLINE | ID: mdl-26219303

Assuntos

Neoplasias Hematológicas/metabolismo; Hematopoese/fisiologia; Células-Tronco Hematopoéticas/metabolismo; Complexo Repressor Polycomb 2/metabolismo; Animais; Imunoprecipitação da Cromatina; Proteína Potenciadora do Homólogo 2 de Zeste; Neoplasias Hematológicas/genética; Camundongos; Camundongos Mutantes; Complexo Repressor Polycomb 2/genética; Transcriptoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Neoplasias Hematológicas / Complexo Repressor Polycomb 2 / Hematopoese Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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