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Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.
Wang, Hui; Liu, Li; Lu, Yang; Pan, Pan; Hooker, Jacob M; Fowler, Joanna S; Tonge, Peter J.
Afiliação
  • Wang H; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
  • Liu L; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
  • Lu Y; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
  • Pan P; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States.
  • Hooker JM; Biological, Environmental and Climate Sciences Department, Brookhaven National Laboratory, Upton, NY 11973, United States.
  • Fowler JS; Biological, Environmental and Climate Sciences Department, Brookhaven National Laboratory, Upton, NY 11973, United States.
  • Tonge PJ; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, United States. Electronic address: peter.tonge@stonybrook.edu.
Bioorg Med Chem Lett ; 25(21): 4782-4786, 2015 Nov 01.
Article em En | MEDLINE | ID: mdl-26227776
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Éteres Fenílicos / Proteínas de Bactérias / Antirreumáticos / Tomografia por Emissão de Pósitrons / Inibidores Enzimáticos / Antibacterianos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Éteres Fenílicos / Proteínas de Bactérias / Antirreumáticos / Tomografia por Emissão de Pósitrons / Inibidores Enzimáticos / Antibacterianos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article