Nutridynamics: mechanism(s) of action of bioactive compounds and their effects.
Int J Food Sci Nutr
; 66 Suppl 1: S22-30, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-26241008
ABSTRACT
Mechanism of action of bioactive compounds may be multiple, especially in the food matrix. Therefore, the interplay between these compounds and hosts' physiology, and the consequences of its continuous intake should be considered. In analogy with pharmacodynamics, the bioactive compounds should have both defined targets and mechanisms of action. However, several essential differences arise when considering the heterogeneous nature of the food matrix, the multiplicity of mechanisms and the variety of responses. In order to ascertain a potential mechanism of activity, one should consider both the intended use of the food, the biomarker that will support this claim and previous evidences, examined from current information sources. Once these have been examined, several experimental strategies should be considered, ranging from the choice of preclinical or experimental model, the use of samples from pilot interventional studies and the application of system's biology derived techniques, such as transcriptomics or metabolomics.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciências da Nutrição
/
Análise de Alimentos
/
Fenômenos Fisiológicos da Nutrição
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article