NNMT: A Bad Actor in Fat Makes Good in Liver.

Trammell, Samuel A J; Brenner, Charles

Trammell, Samuel A J; Brenner, Charles.

Afiliação

Trammell SA; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Brenner C; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242; Obesity Research & Education Initiative, Carver College of Medicine, University of Iowa, Iowa City, IA 52242. Electronic address: charles-brenner@uiowa.edu.

Cell Metab ; 22(2): 200-1, 2015 Aug 04.

Article em En | MEDLINE | ID: mdl-26244929

ABSTRACT

ABSTRACT

High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.

Assuntos

Fígado/metabolismo; Nicotinamida N-Metiltransferase/fisiologia; Sirtuína 1/fisiologia; Animais; Feminino; Humanos; Masculino

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nicotinamida N-Metiltransferase / Sirtuína 1 / Fígado Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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