Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode.

Sugimoto, Hiroshi; Kakehi, Masaaki; Satomi, Yoshinori; Kamiguchi, Hidenori; Jinno, Fumihiro

Sugimoto, Hiroshi; Kakehi, Masaaki; Satomi, Yoshinori; Kamiguchi, Hidenori; Jinno, Fumihiro.

Afiliação

Sugimoto H; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited.
Kakehi M; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited.
Satomi Y; Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited.
Kamiguchi H; Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited.
Jinno F; Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited.

J Sep Sci ; 38(20): 3516-24, 2015 Oct.

Article em En | MEDLINE | ID: mdl-26249017

Assuntos

Pressão Atmosférica; Hidroxicolesteróis/sangue; Extração Líquido-Líquido; Cromatografia Líquida de Alta Pressão; Feminino; Humanos; Masculino; Controle de Qualidade; Espectrometria de Massas em Tandem

Palavras-chave

24S-Hydroxycholesterol; Atmospheric pressure chemical ionization; Chromatographic separation; Saponification; Surrogate matrices

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Atmosférica / Extração Líquido-Líquido / Hidroxicolesteróis Limite: Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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