Validation of warfarin pharmacogenetic algorithms in 586 Han Chinese patients.
Pharmacogenomics
; 16(13): 1465-74, 2015.
Article
em En
| MEDLINE
| ID: mdl-26255607
ABSTRACT
AIM:
To compare the accuracy of the nine selected algorithms for predicting warfarin dose with 586 Han Chinese patients. MATERIALS &METHODS:
Genotyping of VKORC1 1639G>A, CYP2C9*2 and CYP2C9*3 variants was performed. Both the mean absolute error and ideal estimation value were used for comparison.RESULTS:
The top three performers were from East Asians. The algorithms from Caucasians generally performed better in the medium-dose subgroup (>3 and <7 mg/day), while the algorithms from East Asians generally performed better in the low-dose subgroup (≤ 3 mg/day). None of the algorithms performed well in the high-dose subgroup (≥ 7 mg/day).CONCLUSION:
Algorithms built for specific ethnic groups and preassigned-dose groups are suggested for better prediction.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
/
Varfarina
/
Algoritmos
/
Anticoagulantes
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
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Aged80
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article