Clinical pharmacological studies on centpropazine--a new antidepressant compound.
Indian J Med Res
; 90: 360-2, 1989 Oct.
Article
em En
| MEDLINE
| ID: mdl-2628304
ABSTRACT
Single oral doses of 10 to 160 mg centpropazine, a new antidepressant (synthesized by CDRI, Lucknow, India) were administered to groups of 4-5 male volunteers, each dose being interspersed with placebo in a double blind, non-crossover study by random distribution. The drug was well tolerated. Drowsiness, heaviness, weakness and/or headache were reported only at doses of 120 mg and above. No adverse effect was noted in various laboratory tests, ECG or vital parameters. In a multiple dose study, volunteers received 40 or 80 mg centpropazine daily for 4 wk. Mild restlessness and insomnia were observed in some subjects receiving 80 mg dose. In this study also no effect was observed in various laboratory tests, ECG or vital parameters.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antidepressivos
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Aged
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article