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Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.
Farha, Maya A; Czarny, Tomasz L; Myers, Cullen L; Worrall, Liam J; French, Shawn; Conrady, Deborah G; Wang, Yang; Oldfield, Eric; Strynadka, Natalie C J; Brown, Eric D.
Afiliação
  • Farha MA; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8N 3Z5;
  • Czarny TL; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8N 3Z5;
  • Myers CL; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8N 3Z5;
  • Worrall LJ; Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z3;
  • French S; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8N 3Z5;
  • Conrady DG; Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z3;
  • Wang Y; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
  • Oldfield E; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
  • Strynadka NC; Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada V6T 1Z3;
  • Brown ED; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5; Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8N 3Z5; ebrown@mcmaster.ca.
Proc Natl Acad Sci U S A ; 112(35): 11048-53, 2015 Sep 01.
Article em En | MEDLINE | ID: mdl-26283394
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Parede Celular / Alquil e Aril Transferases / Inibidores Enzimáticos Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Parede Celular / Alquil e Aril Transferases / Inibidores Enzimáticos Idioma: En Ano de publicação: 2015 Tipo de documento: Article