Auditory dysfunction in schizophrenia: integrating clinical and basic features.
Nat Rev Neurosci
; 16(9): 535-50, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-26289573
ABSTRACT
Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent psychosocial disability in affected individuals. Although studies of schizophrenia have traditionally focused on deficits in higher-order processes such as working memory and executive function, there is an increasing realization that, in this disorder, deficits can be found throughout the cortex and are manifest even at the level of early sensory processing. These deficits are highly amenable to translational investigation and represent potential novel targets for clinical intervention. Deficits, moreover, have been linked to specific structural abnormalities in post-mortem auditory cortex tissue from individuals with schizophrenia, providing unique insights into underlying pathophysiological mechanisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Psicologia do Esquizofrênico
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Córtex Auditivo
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Vias Auditivas
/
Estimulação Acústica
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article