Nanosuspensions as delivery system for gambogenic acid: characterization and in vitro/in vivo evaluation.

Yuan, Huiling; Li, Xin; Zhang, Caiyun; Pan, Wenli; Liang, Yumeng; Chen, Yang; Chen, Weidong; Liu, Lulu; Wang, Xiaomin

Yuan, Huiling; Li, Xin; Zhang, Caiyun; Pan, Wenli; Liang, Yumeng; Chen, Yang; Chen, Weidong; Liu, Lulu; Wang, Xiaomin.

Afiliação

Yuan H; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Li X; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Zhang C; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Pan W; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Liang Y; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Chen Y; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Chen W; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Liu L; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.
Wang X; a Pharmacokinetics Laboratory , School of pharmacy, Anhui University of Chinese Medicine, Anhui Academy of Chinese Medicine , Hefei , People's Republic of China.

Drug Deliv ; 23(8): 2772-2779, 2016 Oct.

Article em En | MEDLINE | ID: mdl-26292058

Assuntos

Nanopartículas/química; Suspensões/química; Xantenos/administração & dosagem; Xantenos/química; Animais; Disponibilidade Biológica; Linhagem Celular Tumoral; Química Farmacêutica/métodos; Composição de Medicamentos/métodos; Sistemas de Liberação de Medicamentos/métodos; Estabilidade de Medicamentos; Excipientes/química; Feminino; Liofilização/métodos; Meia-Vida; Células Hep G2; Humanos; Masculino; Nanopartículas/administração & dosagem; Tamanho da Partícula; Polietilenoglicóis; Polivinil/química; Ratos; Ratos Sprague-Dawley; Solubilidade; Solventes/química; Tensoativos/química; Suspensões/administração & dosagem

Palavras-chave

Cytotoxicity; gambogenic acid; in vitro release; in vivo pharmacokinetics; nanosuspensions

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Suspensões / Xantenos / Nanopartículas Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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