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Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.
Kunz, Joachim B; Rausch, Tobias; Bandapalli, Obul R; Eilers, Juliane; Pechanska, Paulina; Schuessele, Stephanie; Assenov, Yassen; Stütz, Adrian M; Kirschner-Schwabe, Renate; Hof, Jana; Eckert, Cornelia; von Stackelberg, Arend; Schrappe, Martin; Stanulla, Martin; Koehler, Rolf; Avigad, Smadar; Elitzur, Sarah; Handgretinger, Rupert; Benes, Vladimir; Weischenfeldt, Joachim; Korbel, Jan O; Muckenthaler, Martina U; Kulozik, Andreas E.
Afiliação
  • Kunz JB; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Rausch T; Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany European Molecular Biology Laboratory (EMBL), Genomics Core Facility, Heidelberg, Germany.
  • Bandapalli OR; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Eilers J; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
  • Pechanska P; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
  • Schuessele S; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany.
  • Assenov Y; Division of Epigenomics and Cancer Risk Factors, The German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Stütz AM; Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
  • Kirschner-Schwabe R; Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany.
  • Hof J; Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Eckert C; Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany.
  • von Stackelberg A; Department of Pediatric Oncology/Hematology, Charité - Universitätsmedizin Berlin, Germany.
  • Schrappe M; Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
  • Stanulla M; Department of Pediatric Hematology/Oncology, Medical School Hannover, Germany.
  • Koehler R; Department of Human Genetics, University of Heidelberg, Germany.
  • Avigad S; Molecular Oncology, Felsenstein Medical Research Center and Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
  • Elitzur S; Molecular Oncology, Felsenstein Medical Research Center and Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
  • Handgretinger R; Children's Hospital, University Hospital Tübingen, Germany.
  • Benes V; European Molecular Biology Laboratory (EMBL), Genomics Core Facility, Heidelberg, Germany.
  • Weischenfeldt J; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
  • Korbel JO; Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de jan.korbel@embl-heidelberg.de.
  • Muckenthaler MU; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulozik@med.uni-heidelberg.de jan.korbel@embl-heidelberg.
  • Kulozik AE; Department of Pediatric Oncology, Hematology and Immunology, Children's Hospital, University of Heidelberg, Germany Molecular Medicine Partnership Unit, EMBL-University of Heidelberg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany Martina.Muckenthaler@med.uni-heidelberg.de Andreas.Kulo
Haematologica ; 100(11): 1442-50, 2015 Nov.
Article em En | MEDLINE | ID: mdl-26294725
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA de Neoplasias / Regiões Promotoras Genéticas / Metilação de DNA / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Mutação Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA de Neoplasias / Regiões Promotoras Genéticas / Metilação de DNA / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Mutação Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article