Mathematical modeling of receptor occupancy data: A valuable technology for biotherapeutic drug development.

Spilker, Mary E; Singh, Pratap; Vicini, Paolo

Spilker, Mary E; Singh, Pratap; Vicini, Paolo.

Afiliação

Spilker ME; Department of Pharmacokinetics, Dynamics and Metabolism-New Biological Entities, Pfizer Worldwide Research and Development, San Diego, California.
Singh P; Department of Pharmacokinetics, Dynamics and Metabolism-New Biological Entities, Pfizer Worldwide Research and Development, Cambridge, Massachusetts.
Vicini P; Department of Pharmacokinetics, Dynamics and Metabolism-New Biological Entities, Pfizer Worldwide Research and Development, San Diego, California.

Cytometry B Clin Cytom ; 90(2): 230-6, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26296748

Assuntos

Anticorpos Monoclonais/isolamento & purificação; Descoberta de Drogas; Citometria de Fluxo; Modelos Teóricos; Anticorpos Monoclonais/uso terapêutico; Simulação por Computador; Humanos

Palavras-chave

antibody; biotherapeutics; modeling; pharmacodynamics; pharmacokinetics; receptor occupancy; site-of-action

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Citometria de Fluxo / Modelos Teóricos / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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